Nexium just like other Proton pump inhibitors which carries out their action on the body by inhibiting the enzyme ATPase located in the gastric parietal cells and by this action they ultimately reduce gastric acid secretions. This is the reason why Nexium is used in the treatment of GERD (gastroesophargeal reflux disease), symptoms that results from Zollinger - Ellison syndrome, for promoting healing in erosive esophagitis (this condition is damage to the esophagus that is as a result of excess acid in the stomach). The use of Nexium in the treatment of duodenal and gastric ulcer is well known especially in ulcers that was caused by helicobacter pylori or ulcers which are as a result of prolonged use of NSAIDs (non- steroidal anti-inflammatory drugs).

Therapeutic Uses Of Nexium: The therapeutic uses of Nexium have already been listed above. For the healing of erosive esophagitis, Nexium is used for four to eight weeks in the healing and the symptomatic treatment of this disease when it is diagnostically confirmed. If Nexium therapy is used for four to eight weeks and there is no positive result the therapy can be continued for another four to eight weeks while the patient is under surveillance and continual medical checkup.
Nexium is also the drug of choice for the short term treatment and management of heart burn,Nexium dosage is also given for one to two months to results to be achieved with this therapy. For the treatment of gastric infection of helicobacter pylori which is often seen in gastric and duodenal ulcers or gastritis Nexium is used with two antibiotics (Erythromycin and Amoxicillin) as triple therapy to eradicate this bacterial infection that can lead to more sever conditions. If after some weeks of administration the bacteria are still found in serological test, Nexium is also used in the quadruple therapy that is administered. Nexium is also indicated in patients who are at high risk of having gastric ulcers when they have used NSAIDs for long time and since this group of drug usually exposes patients to gastric ulcer formation, Nexium helps to reduce the risk of ulcers in patients that are susceptible to the formation of the ulcers.

Dosage Of Nexium: The dosage of Nexium is dependent on the disease and the efficiency of Nexium therapy on the patients that the drug is administered to. For GERD and healing esophagitis the recommended dose of Nexium is 20mg or 40mg (depending on the patient`s condition) once a day for 4-6 weeks. For NSAID related gastric condition the dosage is 20mg or 40mg one time a day for six months and the dosage for triple therapy is; Nexium 40mg one time/day, Erythromycin 500mg once/day , Amoxicillin 500mg once/day, all which are taken for 10days.

Side Effects Of Nexium: The common side effects that is seen with the use of Nexium are; headache, dry mouth, nausea, diarrhea, constipation, loss of appetite, severe allergic reaction, chest pain,palpitations(increased heart beat), darkened urine, unexplainable bruising with unusual bleeding, severe stomach cramps, persistent and continuous sore throat, tiredness and fatigue, yellowing of the skin and sclera. Nexium is also connected with pneumonia in prolonged use.
The use of Nexuim and other proton pump inhibitors are very useful in medical science because these groups of drugs are used in intensive care of patients to prevent ulcer formation and also the treatment of ulcers.

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